【摘 要】
：
Organometallic Ru(Ⅱ)/Os(Ⅱ)arene complexes of the type [(η6-arene)Ru(en)Cl]+,[1] where the arene = e.g.p-cymene,biphenyl(bip)or tetrahydroanthracene(tha)a
【机 构】
：
School of Chemistry and Material Science,Nanjing Normal University,Wenyuan Road 1,Nanjing 210023
【出 处】
：
2018中西部地区无机化学化工学术研讨会
论文部分内容阅读
Organometallic Ru(Ⅱ)/Os(Ⅱ)arene complexes of the type [(η6-arene)Ru(en)Cl]+,[1] where the arene = e.g.p-cymene,biphenyl(bip)or tetrahydroanthracene(tha)and en = ethylenediamine,are toxic to cancer cells,including cisplatin-resistant cell lines.Our results[1,2] show that there two kinds of intercalation of Ru-arene into DNA,including classic and a novel penetrating intercalation.We also relate these dual mode interactions(coordination and intercalation)to the mechanism of anticancer activity and to structure-activity relationships.In addition,we find that the interactions between these complexes and DNA show close similarities to those of covalent polycyclic aromatic carcinogens.
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