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针对中药质量生物评价与控制中面临的重要技术问题——工作参照物的选择与标化,以黄连质量生物评价控制为例,从基原鉴定、常规检查、化学组分分析和生物测定等角度对其工作参照物(道地药材提取物)的研制过程进行阐释,凝炼共性技术,形成具有普适性的中药质量生物评价与控制用工作参照物的选择与标化流程,以期为构建基于道地药材和生物测定的中药质量控制模式与方法提供技术参考。
According to the selection and standardization of the work reference material, which is an important technical problem in quality assessment and control of Chinese medicine, taking the quality control of the quality control of Coptis chinensis as an example, from the aspects of basic identification, routine examination, chemical composition analysis and bioassay This paper explains the research process of its work reference (extract of medicinal plants), concludes the common technology and forms a universal selection and standardization process of the work reference materials for evaluation and control of quality of Chinese traditional medicine. Authentic medicine and bioassay of traditional Chinese medicine quality control methods and methods to provide technical reference.