The target therapy development in lung cancer-data from chinese clinical trails

来源 :第五届21世纪中美医学论坛(The 5th Sino-US Symposium on Medicine in the 2 | 被引量 : 0次 | 上传用户:zxw2yanzi
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  The phase Ⅲ randomised BR.21 study demonstrated that in patients with relapsed advanced NSCLC, erlotinib (Tarceva) improved survival and prolonged time to symptom deterioration compared with placebo (Shepherd et al.NEJM 2005 ;353:123 32).Erlotinib was well tolerated, with rash and diarrhoea the most common adverse events (AEs) , both being generally mild to moderate in severity.The TRUST study was designed to allow access to erlo tinib for eligible patients in countries where the drug had not yet received a licence.More than 7,040 patients have been enrolled into this open-label, non-randomised study at 552 centres in 52 countries worldwide.Methods : Eligi ble patients with stage ⅢB/Ⅳ NSCLC had failed previous chemotherapy for advanced disease (≤ 2 prior regi mens) or were unsuitable for chemotherapy.Erlotinib was administered orally 150mg/day until disease progression or unacceptable toxicity.366 patients in China were included in the analysis at the data cut-off (06/06/07).Dis ease Control Rate is 81% (PR 23% ,SD 58%).86% of them experienced rash, only 4% of them with grade >2 rash.Incidence of Tarceva-related SAE is 2%.
其他文献
最近,美国国立综合癌症网(National Comprehensive Cancer Network,NCCN)公布了《2012宫颈癌临床实践指南》。本文对该指南进行简要的介绍和解读。1《2012宫颈癌临床实践指南
近年来的研究结果表明,轻度维生素A缺乏(夜盲和/或毕脱氏斑)与儿童肠道、呼吸道等感染性疾病的发病率和死亡率明显相关。已知维生素A与维持正常视觉有密切关系,并对上皮细胞
  With rapid revolution in technology and medicine, many new imaging tools are or will be available in clinical research and practice.The evidence-based evalu
会议
我们要Quake4Q u a k e4刚开始发售没有多久,很多人都已经无法自拔了。至今,还有很多测试中都在使用的Q u a k e3,依然有无数电子竞技爱好者,包括大批玩家对其热情不减。享受
1998年《国务院关于进一步深化城镇住房制度改革加快住房建设的通知》发布后,住房消费有效启动,使房地产业塑造了众多的、各具特点的企业家,他们带领企业团队,创造了宝贵的
  China is an ancient civilized country, its traditional Chinese medicine is based on individual experiences, the morality of traditional medicine has long hi
会议
  A platform nanodelivery system has been developed comprising a self assembled, biodegradable, cationic lipo somal nanoparticle, which bears targeting molecu
会议
  The goal of hospital based healthcare is to assure that each patient receives the correct diagnosis and the proper treatment at the lowest possible cost.In
会议
会议
会议