Chiral α-substituted heterocycles,such as tetrahydrofurans,tetrahydropyrans,pyrrolidines,piperidines,and more complex derivatives,are one of the most common structural motifs spread across numerous bioactive natural products and synthetic pharmaceuticals.Traditional synthetic strategies typically rely on the enantioselective intramolecular transformations of pre-existing functional groups,which usually involve multiple and unproductive steps for reactive functionality incorporation.Moreover,the construction of different heterocycle skeletons typically required completely different synthetic strategy,and a universal and practical strategy for the enantioselective preparation of diverse α-substituted heterocycles has never been developed.