【摘 要】
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Background: The enhanced brown adipose tissue (BAT) activity and "browning" of white adipose tissue (WAT) can promote the expenditure of excess stored energy,and reduce prevalence of obesity and assoc
【机 构】
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Nanjing Maternity and Child Health Care Institute, Nanjing Maternity and Child Health Care Hospital,
【出 处】
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西部新生儿论坛暨中国儿童早期健康发展论坛
论文部分内容阅读
Background: The enhanced brown adipose tissue (BAT) activity and "browning" of white adipose tissue (WAT) can promote the expenditure of excess stored energy,and reduce prevalence of obesity and associated metabolic diseases.Cold is known as a potent stimulator of BAT,activating BAT primarily through the β3-adrenergic-cAMP signaling,miRNAs have been regarded as molecular regulators involved in metabolically activated mouse BAT,however,few studies focus on miRNA expression in human brown adipocytes.The aims of this study were to set up a cold-stimulated mouse BAT miRNA profile and compare differential miRNAs in mouse and human brown adipocytes in vitro upon β3-adrenergic-cAMP signaling stimulation,further increasing our understanding on human BAT function and providing potential molecular therapeutic targets to increase excess energy and treat obesity.
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