黄曲霉毒素诱导巨噬细胞自噬机制的研究

来源 :中国畜牧兽医学会兽医药理毒理学分会第十一届会员代表大会暨第十三次学术讨论会与中国毒理学会兽医毒理专业委员会第五次学术研讨 | 被引量 : 0次 | 上传用户：laobo999

【摘要】

：

黄曲霉毒素是一种各种食物广泛存在的毒素，具有很强的致癌性.因此，黄曲霉毒素被认为是引起公共卫生问题的罪魁祸首，而黄曲霉毒素B1 (AFB1)是黄曲霉家族中毒性最强的一员.然而，人们对黄曲霉毒素B1和动物机体先天免疫一自噬之间的关系报道很少.在本研究中，我们发现黄曲霉毒素B1能过诱导巨噬细胞(包括RAW264.7和THP-1)和Hela细胞发生完全自噬，而且依赖MEK/ERK途径，并与Beclin-

【作者】

：

施晓晨安雅男申凤鸽于录

【机构】

：

吉林大学人兽共患病研究所,人兽共患病研究教育部重点实验室,吉林大学动物医学学院,吉林大学动物科学学院,吉林长春130062

【出处】

：

中国畜牧兽医学会兽医药理毒理学分会第十一届会员代表大会暨第十三次学术讨论会与中国毒理学会兽医毒理专业委员会第五次学术研讨

【发表日期】

：

2015年9期

【关键词】

：

黄曲霉毒素B1 天然免疫自噬巨噬细胞

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黄曲霉毒素诱导巨噬细胞自噬机制的研究

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