Somatostatins (SSs) can modulate growth, energy distribution, digestion and metabolism in adult vertebrates.However, not too much is known about its role in embryos.We investigated expression pattern of SS in early developmental stages of zebrafish embryo using in situ hybridization.SS2 mRNA expressed in inner ear primodia, and could maintain its expression in neurosecretory preoptic nucleus and posterior tuberculum until 3 days post fertilization.