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  5. Functional Abnormalities and Regulatory Mechanisms of Plasmacytoid Dendritic Cells in the Developmen

Functional Abnormalities and Regulatory Mechanisms of Plasmacytoid Dendritic Cells in the Developmen

来源 :中国免疫学会第九届全国免疫学学术大会 | 被引量 : 0次 | 上传用户：lf7891
【摘 要】
：
Background and aims: Systemic lupus erythematosus (SLE) is a chronic multi-organ autoimmune disease with immunological features of a prominent "interferon (IFN) signature", which is marked by the elev
【作 者】
：
Sheng YAN C.S.LAU Vera S.F.CHAN 
【机 构】
：
Department of Medicine, The University of Hong Kong, Pokfulam, Hong Kong
【出 处】
：
中国免疫学会第九届全国免疫学学术大会
【发表日期】
：
2014年8期
【关键词】
：
Systemic lupus erythematosus plasmacytoid dendritic cells microRNA 
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Background and aims: Systemic lupus erythematosus (SLE) is a chronic multi-organ autoimmune disease with immunological features of a prominent "interferon (IFN) signature", which is marked by the elevated expression of type Ⅰ IFNregulated genes in blood and tissue cells of patients with this condition.Plasmacytoid dendritic cells (pDCs), the most potent type Ⅰ IFN-producing cells, are previously found to be hyperactive in SLE.Using the New Zealand Black/White F 1 lupus mouse model, the current study sought for the regulatory mechanism of IFN production by pDCs in SLE.
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