【摘 要】
：
目的 The aim of this observational study was to investigate the influence of continuous positive airway pressure(CPAP) on arterial blood gas and lactate, markers of tissue hypoxia, among obstructive sle
【机 构】
：
First Affiliated Hospital of Fujian Medical University
【出 处】
：
2016中华医学会呼吸病学年会暨第十七次全国呼吸病学学术会议
论文部分内容阅读
目的 The aim of this observational study was to investigate the influence of continuous positive airway pressure(CPAP) on arterial blood gas and lactate, markers of tissue hypoxia, among obstructive sleep apnea syndrome (OSAS) patients, and determine the risk factor of serum lactate and PH in OSAS patient 方法 One-hundred and nine patients with newly diagnosed OSAS were enrolled in the study.All individuals were treated with CPAP for one night.Venous lactate and arterial blood gas were gathered from all subjects in the morning at the end of polysomnography, and the next morning after CPAP treatment.结果 Of the 109 selected subjects, average lactate were 2.23±0.59, and mean PH, PaO2, PaCO2 were 7.380±0.23, 88.14±17.83 38.70±4.28,respectively.Compared to baseline, lactic acid significantly reduced (2.10±0.50, p=0.03), while PH increased remarkly (7.388±0.27, p＜0.05) after CPAP treatment.In addition, age, neck circumference and the polysomnographic parameters, including AHI, ODI, mean SPO2 and TS90％were correlated with lactate (all p＜0.05), and significantly associations were found between age, neck circumference, ODI and PH.Finally, after adjusting for confounding factors, TS90％ was the major contributing predictor for increased lactate(p＜0.05), and age significantly predicated the PH(p＜0.05).结论 The results indicate that CPAP treatment can reduce serum lactate and increase PH in OSAS patients, and may alleviate acidbase disorders in OSA.Furthermore, TS90％ was a risk factor for elevated lactate, and age was independently associated with PH.
其他文献
目的 探讨经鼻气道持续正压通气(nCPAP)对阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者夜尿次数增多的改善作用.方法 选择2014年6月至2016年5月夜尿次数增多的中重度OSAHS患者74例,其中中度(15≤AHI≤30)14例、重度(30≤AHI＜60)31例和极重度(60≤AHI)29例,进行Auto-nCPAP滴定、记录n-CPAP滴定当晚平均压力及治疗前后夜尿次数,并对其结果进行统
目的 探讨无创呼吸机治疗OSAHS的临床疗效.方法 对本睡眠室经无创呼吸机治疗的OSAHS的患者111例,随访观察Auto-CPAP治疗1月-3年后的AHI指数、临床症状及合并症的情况.结果 111例OSAHS患者治疗前出现不同程度的夜间打鼾、反复呼吸暂停及憋醒、噩梦、晨起头痛头晕、口干、记忆力下降、夜尿增多、白天嗜睡等症状,Auto-CPAP治疗后症状基本缓解；治疗前AHI(41.71±23.8
目的 检测睡眠呼吸暂停低通气综合征(OSASH)患者外周血淋巴细胞免疫表型及C反应蛋白(CRP)变化,探讨OSASH对机体免疫功能及炎症反应的影响.方法 根据多导睡眠监测结果,将受试者分为健康对照组40例,轻中度OSASH患者12例,重度OSASH患者23例.采集患者分别采用流式细胞仪检测受试者外周血淋巴细胞免疫表型,检测血CRP值.结果 OSASH组外周血CD3+、CD4+/CD3+、CD4+/
目的 研究OSA小鼠模型中EPCs修复机制.方法 C57BL/6J雄性小鼠： control、mild IH,moderate IH,severe IH.流式测不同分类EPCs, ELISA测血中SDF-1α,VEGF和HIF-1α.培养外周血单核细胞计算Ac-LDL、UEA-I双染梭形细胞数.不同程度IH EPCs与ECs共培养后,transwell测EPCs迁移数.结果 CD133+KDR+E
目的 OSA是一个由多种病因导致患者睡眠中上气道异常狭窄和续发IH为主要病理特征的睡眠呼吸疾病.目前OSA被普遍认为是一个全身性疾病,其合并症可波及到多个系统器官.近年流行病学调查显示OSA患者肿瘤的发病率及致死率均增高,并且与其严重程度呈正相关.研究发现,作为OSA的两大主要致病因素,间歇低氧和睡眠片段化在肿瘤的发生及发展中被证实起着重要作用,IH可以激活多种氧化还原敏感的转录因子,包括HIF、
目的 Obstructive sleep apnea (OSA) has been recently associated with tumor incidence and cancer-related mortality.Intermittent hypoxia (IH) mimicking OSA contributes to tumor growth and metastasis in a
目的 Its reported that obstructive sleep hypopnea apnea syndrome (OSHAS) is a complex disease with a strong genetic basis, and as well an association with hypoadiponectinemia.Therefore, the objective of
目的 观察中重度OSAHS患者在CPAP联合羧甲司坦和单纯CPAP治疗前后临床症状、PSG相关参数、血管内皮功能及氧化水平变化情况,探讨CPAP联合羧甲司坦抗氧化治疗在合并高血压的OSAHS患者中的应用价值.方法 收集2015年3月至2016年1月期间在广州医科大学附属第一医院呼吸疾病研究所经PSG确诊未经治疗的中重度OSAHS(AHI≥15次/小时)患者.符合入排标准的患者被随机分为CPAP联合
目的 使用Epworth嗜睡量表、PSQI睡眠质量指数及Zung氏抑郁自评表评估中、重度OSAHS患者受疾病影响所致的白天嗜睡、夜晚睡眠质量及心理抑郁情况.方法 观察280例中、重度OSAHS患者三种问卷得分及PSG结果,将之与非OSAHS的对照组人群比较,并分析各量表之间的关系及其与PSG指标的相关性.结果 中、重度OSAHS患者与对照组人群无论是日间嗜睡情况、夜间睡眠质量还是心理抑郁情况均存在
目的 建立间歇低氧/复氧模型,观察间歇低氧/复氧暴露对SD大鼠骨密度的影响并探讨其可能的发病机制.方法 将20只8周龄SD雄性大鼠随机分为间歇低氧(IH)组和常氧对照(NC)组,每组10只放入间歇低氧模拟舱进行间歇低氧/复氧造模,8周后处死,测定股骨质量、骨矿盐含量、血清B-ALP和各部位骨密度(BMD)的表达水平.结果 与NC组相比,IH组B-ALP含量升高,且具有统计学差异(P＜0.05),全