【摘 要】
：
We successfully demonstrated a "killing two birds with one stone" strategy for simultaneous X-ray CT imaging and NIR photothermal therapy (PTT) in vivo with PEGylated WO2.9 NRs.A clear enhancement of
【机 构】
：
The Key Laboratory of Resource Chemistry of Ministry of Education & Shanghai Key Laboratory of Rare
论文部分内容阅读
We successfully demonstrated a "killing two birds with one stone" strategy for simultaneous X-ray CT imaging and NIR photothermal therapy (PTT) in vivo with PEGylated WO2.9 NRs.A clear enhancement of the tumor signal was observed immediately after intratumoral injection of PEGylated WO2.9 NRs, which indicated the feasibility of using these NRs as a CT contrast agent in vivo.
其他文献
Influenza viruses cause a highly contagious respiratory disease in humans, and therefore, the development of novel anti-influenza agents continues to capture significant attention.The non-structural p
膜蛋白具有重要的生理功能,包括物质传递、能量转换和信号传导等.膜蛋白的研究对于生物医药领域的发展起着至关重要的作用,在FDA批准的上市药物中,目前约有一半以膜蛋白作为靶点.但是,限于研究手段,膜蛋白研究还很困难,远远落后于水溶性蛋白.膜蛋白的疏水性决定了其必须依靠合适的去垢剂才能稳定地存在于水溶液中.我们设计了一类基于β-strand/sheet的新型多肽去垢剂(BP).
G-quadruplexes are unique secondary structure exist in various non-coding region of human genome and exhibit important biological roles in the regulation of gene replication, transcription, and transl
Alzheimers disease(AD), the most common dementia in elderly people, is a progressive, neurodegenerative disorder of the brain characterized by loss of memory and cognition.Based on the cholinergic hyp
乙酰乳酸合成酶(AHAS,EC 2.2.1.6)催化支链氨基酸的生物合成,具有生物安全性,是绿色除草剂的重要靶点[1].我们在前期系统研究了单取代磺酰脲类除草剂的构效关系和分子基础[2,3],并且基于AHAS的复合物结构进行分子设计,发现了有用的抑制剂结构信息[4].
D-3-phosphoglycerate dehydrogenase (PGDH) from Escherichia coli catalyzes the first critical step in serine biosynthesis1, and can be allosterically inhibited by serine2.In a previous study, we develo
深海放线菌生活在高压、高盐、寡营养和低温等极端条件下,具备产生新结构药物先导化合物的巨大潜能.在放线菌5-10Mb的基因组遗传信息中,大约5％-10％的DNA序列编码次级代谢产物的生物合成.因此,对深海放线菌进行发酵和筛选并对基因组编码的关键次生代谢过程进行生物信息学分析,可以发现新的药物活性先导化合物、发现新的生物合成途径和新的酶催化反应机制,对其中的结构基因、调控基因和后修饰基因等进行基因突变
细胞通过离子通道与外环境进行物质交换,规律性地调控穿过细胞膜内外分子和离子.近年来,人们发展各种材料的固态纳米孔道对细胞膜离子通道进行模仿,在生物分子检测、模拟生物离子通道功能以及纳米器件的构建等方面都有诸多实际应用.
Aptamers are single-stranded oligonucleotides that can bind their target molecules with high affinity and specificity [1-2].The conventional SELEX process for aptamer generation is time-consuming, lab
色氨酸(Trp)作为人体必需氨基酸,在生物体的生长与调节等方面扮演重要角色.蛋白质中色氨酸残基的异常往往与蛋白质功能紊乱、酶失活进而与癌症等多种疾病密切相关.因此,发展高选择性、简单、快捷的色氨酸及其多肽、蛋白质的检测新方法,对分析化学、医学和生物学研究都具有重要的价值.