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Streptomyces sp.JS01 (Marin Culture Collection of China [MCCC] number MCCC 1F01225) is the producer of the anti-algal compound, which has been shown inhibitory activity against a harmful algal species Phaeocystis globosa, and it also can produce a red pigment.The genome sequence will allow for the characterization of the anti-algal compound and the molecular mechanisms underlying its beneficial properties.