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Background Recently, several randomized trials which compared bivalirudin with heparin plus glycoprotein Ⅱb/Ⅲa inhibitors (GPIs)in patients undergoing percutaneous coronary intervention (PCI)had been published.The purpose of this study was to perform an up-to-date meta-analysis of randomized trials on the effectiveness and safety of bivalirudin vs heparin plus GPIs in patients undergoing PCI.