Backgroud Premature ovarian insufficiency(POI),Premature ovarian failure (POF) is the syndrome that appear persistent amenorrhea and genital atrophy, Accompanied by follicle stimulating hormone (FSH) and luteinizing hormone (LH) increase, while estrogen reduces female before the age of 40.POI is a common gynecologic endocrine disease.It is reported that the incidence rate of POI is 1% in the women less than 40 years、 0.1% in less than 30 years、 0.01% in less than 20 years、 0.5% in China,while 1.4% in foreign.0.1% in Japanese.The cause of POI is complex and diverse.Genetic, autoimmune disease, infection, iatrogenic factors all can cause POI ,but the etiology more than 50% is not clear.Early diagnosis and treatment are significantly important, in case of it has a significant impact on physical and psychological health.Hormone replacement therapy of the main therapies of POI,to relieve menopausal symptoms.