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Fluorescence molecular tomography(FMT)gains increasing interests in deep tissue imaging.Here we report a novel FMT system setup with full angel projections.In this system,a tungsten-halogen lamp is applied as illumination,while a scientific complementary metal oxide semiconductor(sCMOS)is used as a detecting device.With a unique line-pattern illumination and a high sensitivity sCMOS,our FMT system can complete data acquisition over 36 perspective angles along the animal within 10 minutes.We also employ a novel transparent animal bed,which is suitable to hold the animal for long time experiments.Both phantom and in vivo animal experiments have been studied,and our results demonstrate this FMT system has a great potential for small animal study.In addition,our design allows this FMT system to be easily applied in either stand-alone fluorescent systems or combined with other molecular imaging methods.