Adiponectin-derived active peptide ADP355 exerts anti-inflammatory and anti-fibrotic activities in t

来源 :中国免疫学会第十届全国免疫学学术大会 | 被引量 : 0次 | 上传用户:king1981001
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Background & Aims: Adiponectin is an adipocyte-derived circulating protein with beneficial effects on liver injury.Mice lacking of adiponectin develops an enhanced liver fibrosis, suggest adiponectin could be a therapeutic target for liver injury.
其他文献
Obesity has been a globle metabolism disease since last two decades.The main character of obesity is the accumulation of fat with long chronic inflammation.Obesity increases the risk of developing a w
Aim: Glibenclamide, originally applied to treat type 2 diabetes mellitus, is currently known to exert a new pharmacological effect.In this study we explored the possible inhibitory effect of glibencla
Background: Forkhead box P3(Foxp3) is known as the optimum maker for regulatory T cells(Tregs), which are conventionally thought to induce immune tolerance to disturb the antitumor immunity.However, t
Japanese encephalitis virus (JEV) is a mosquito-borne neurotropic virus, which can escape from the peripheral immune clearance leading to neuropathogenisis.However, the mechanism of JEV immune evasion
目的:空间飞行中,模拟失重环境导致机体免疫功能发生紊乱,其发生机制尚不明确,近年研究表明miRNA在免疫系统的发育和功能中起重要作用,它也有可能参与了空间失重条件下的免疫功能调节,本研究通过观察模拟失重下小鼠淋巴细胞功能变化,及其miRNA表达变化,寻找失重免疫效应的机制。
目的:检测B7-H4受体在B细胞表面的表达,研究B7-H4蛋白对细胞增殖和细胞凋亡的影响,探讨B7-H4通过未知受体传递的下游信号机制。方法:使用用anti-CD19抗体包被的磁珠分选出扁桃体中CD19+B细胞,通过流式细胞术检测CD19+B细胞的受体的表达情况;采用CCK8法和annexin V/PI凋亡试剂盒分别检测B细胞增殖和细胞凋亡;进一步采用Western Blot检测凋亡信号通路的AK
Abnormalities in B cell survival can lead to altered B cell activation and differentiation, resulting in immunological disorders such as immunodeficiencies and autoimmune diseases.
目的:检测原发性干燥综合征(pSS)患者外周血调节性B细胞(Breg)与IL10、TGF-β1水平变化,探讨Breg细胞变化与IL10、TGF-β1表达水平之间的相关性。方法:采用流式细胞术检测51例治疗前、治疗后pSS患者和43例健康体检者(正常对照组)外周血中Breg细胞的百分率,同时采用酶联免疫吸附试验(ELISA)测定其IL10、TGF-β1的表达水平,并对Breg细胞、IL10和TGF-
Tim-3 is well known to interact with its natural ligand, Galectin9, to dampen Th1 immunity and promote peripheral tolerance.However, the function of Galectin/Tim-3 signaling in human pregnancy remains
Objective: To characterize CTRP4 as an anti-obesity adipokine Methods: Bioinformatics analysis;Adipocyte differentiation;Diet-Induced Obesity;Real-time PCR;Western Blot Result: Bioinformatics analysis