【摘 要】
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Autophagy,an evolutionarily conserved lysosomal degradation pathway,has been implicated in a wide variety of cellular processes,and the underlying mechanisms have been extensively studied.Yet,the fusi
【机 构】
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Department of physiology,University of Hong Kong,Hong Kong
【出 处】
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第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会
论文部分内容阅读
Autophagy,an evolutionarily conserved lysosomal degradation pathway,has been implicated in a wide variety of cellular processes,and the underlying mechanisms have been extensively studied.Yet,the fusion between autophagosome and lysosome is poorly understood.Nicotinic acid adenine dinucleotide phosphate (NAADP),an endogenous Ca2+mobilizing nucleotide,mobilizes Ca2+from acidic organelles,e.g.lysosome,through two pore channel 2(TPC2).Here we reported that overexpression of TPC2 in Hela cells,which lack the expression of endogenous TPC2,inhibited the fusion between autophagosome and lysosome by raising lysosomal pH,whereas overexpression of a TPC2 inactive mutant failed to inhibit the fusion.
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