Breast cancer serious threats to human health, the incidence rate is increased about 1% annually estimated that there are more than one million new breast cancer patients in the world each year.HER2 is a major risk associated gene of breast cancer, about 20% to 30% of breast cancer patients with HER2 over-expression.Humanized anti-HER2 monoclonal antibody can be used to treat tumors which over-expressing the HER2 receptor.