Neuronal PAS domain protein 3 plays a critical role in lung development and homeostasis

来源 :2012全国发育生物学大会 | 被引量 : 0次 | 上传用户:qiuzhizhedetiantang
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  Trachealess (Trh), a member of bHLH-PAS transcription factor family, is the master regulator of formation of Drosophila respiratory system.Other proteins regulating Drosophila tracheogenesis downstream from Trh include Breathless (FGFR), Branchless (FGF), Sprouty and Notch.Many genes regulating Drosophila tracheogenesis have been demonstrated to have their functional homologs in the mammalian lung development, but the mammalian homolog of trh has not been previously reported.
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