【摘 要】
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Conventional cell-penetrating peptides (CPPs)-mediated intracellular drug delivery systems are limited by lack of target selectivity.To solve this dilemma,t
【机 构】
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Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Beijing 100850,China
【出 处】
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The Third Symposium on Innovative Polymers for Controlled De
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Conventional cell-penetrating peptides (CPPs)-mediated intracellular drug delivery systems are limited by lack of target selectivity.To solve this dilemma,tumor microenvironment stimulusresponsive nanostructures have been introduced to build "off-on" switches to CPP activity based on sensitivity to external triggers (e.g.,light and temperature) or endogenous triggers (e.g.,enzymatic activity and pH).Light is an ideal external signal,which is non-invasive and can be well controlled.It was reported that 4,5-dimethoxy-2-nitrobenzyl chloroformate (Nvoc) is easily cleaved by UV radiation (365 nm) and photo-irradiation within 10 min was enough to induce the molecular fracture of labile 2-nitrobenzyl moieties,which impose little toxicity to cells but can trigger drug release [1].
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