【摘 要】
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Aim Circulating urotensin Ⅱ (UII) is involved in the development of atherosclerosis.However, the role of autocrine UII in the development of atherosclerosis remains unclear.Here, we tested the hypothe
【机 构】
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Laboratory for Lipid Metabolism and Atherosclerosis, Xi'an Jiaotong University Cardiovascular Resea
【出 处】
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第十四届中国西部实验动物管理与学术交流会
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Aim Circulating urotensin Ⅱ (UII) is involved in the development of atherosclerosis.However, the role of autocrine UII in the development of atherosclerosis remains unclear.Here, we tested the hypothesis that autocrine UII would promote atherosclerosis.Methods and results Transgenic rabbits were created as a model to study macrophage-specific expressing human UII (hUII) and used to investigate the role of autocrine UII in the development of atherosclerosis.Transgenic rabbits and their non-transgenic littermates were fed a high cholesterol diet to induce atherosclerosis.Comparing the transgenic rabbits with their non-transgenic littermates, it was observed that hUII expression increased the macrophagea-positive area in the atherosclerotic lesions by 45% and the positive area ratio by 56% in the transgenic rabbits.Autocrine hUII significantly decreased the smooth muscle cell-positive area ratio in transgenic rabbits (by 54%), without affecting the plasma levels of total cholesterol, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol,and glucose and adipose tissue contents.Conclusions These results elucidated for the first time that autocrine UII plays an important role in the development of atherosclerosis by increasing the accumulation ofmacrophage-derived foam cell.
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