采用液相中药物球型结聚技术制备了甲氧氯普胺微丸，并对产品的特性进行了考察。结果表明，产品成形性好，不同批号的产品及同一批号不同粒径的产品主药含量基本一致。微丸具有一定的缓释作用，溶出速率主要决定于乙基纤维素用量及产品粒径大小。制备过程中，甲氧氯普胺与乙基纤维素间可能形成了氢键结合。 Metoclopramide pellets were prepared by liquid-phase drug-based ball-coalescence technique and the properties of the product were investigated. The results showed that the formability of the product is good, the products of different batches and the products of the same batch with different particle sizes are basically the same. Pellets have a sustained release effect, the dissolution rate is mainly determined by the amount of ethyl cellulose and product size. During the preparation, hydrogen bonding may be formed between metoclopramide and ethyl cellulose.