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Ghrelin, an acylated peptide produced in the stomach, increases food intake and growth hormone secretion, inhibits pro-inflammatory cascade, etc.The aim of the present study was to investigate the effects of ghrelin and its receptor agonist GHRP-2 for the first time in the acute pain modulation at the supraspinal level, using the tail withdrawal test in mice.Intracerebroventricular (i.c.v.) administration of ghrelin and GHRP-2 produced antinociceptive effects in the test.Antinociceptive effects elicited by ghrelin and GHRP-2 were significantly antagonized by naloxone and [D-Lys3]-GHRP-6.