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Worldwide spread of Klebsiella pneumoniae with carbapenemase New Delhi metallo-β-lactamase 1(NDM-1)presents major challenge to public health due to limited effective antimicrobials.PPNA06 is a cell penetrating peptide(CPP,(RXR)4XB)conjugated antisense peptide nucleic acids(PNAs)targeting the start codon region of bacterial essential gene rpoD.