Histopathological changes in a critically ill patient with avian influenza A(H7N9)

来源 :2016中华医学会呼吸病学年会暨第十七次全国呼吸病学学术会议 | 被引量 : 0次 | 上传用户:yourwp
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  目的 To describe hstopathological changes in a critically ill patient with avian influenza A(H7N9).方法 A patient with a severe case of avian influenza A(H7N9)was described.结果 A chest computerized tomography(CT)scan showed diffuse ground-glass opacities and consolidation throughout the lungs.A resection of pulmonary bullae in the right middle lobe was performed by video-assisted thoracic surgery(VATS)based on theextracorporeal membrane oxygenation(ECMO)supportive technique on the 23rd day after the onset of symptoms because of aright pneumothorax persistent air leak.The histopathological findings of the resected lung tissue revealed pneumocytehyperplasia and fibroproliferative changes along with diffuse alveolar damage.Bronchoalveolar lavage fluid specimens forinfluenza A(H7N9)virus were continuously positive for more than three weeks,despite oseltamivir treatment,and continuousviral replication significantly prolonged the course of the disease.The patients clinical status continuously deteriorated,with thedevelopment of refractory hypoxemia due to progressive and rapid lung fibrosis,which was confirmed by the final histologicalchanges observed from a limited postmortem biopsy of lung tissue.Pre-terminally,he developed multi-organ failure and died onthe 39th day after symptom onset,despite corticosteroid treatment.
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