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Purpose mTOR, a member of the PIKK family, It belongs to the phosphatidylinositol 3-kinase (PI3K), protein kinase B (Akt/PKB) and mTOR signaling pathway, crucial for cell growth, survival, motility, proliferation, protein synthesis and transcription.Recent studies have demonstrated that INK128 could enhances In vitro and in vivo radiosensitivity of pancreatic carcinoma cells.