Objective: To explore the long-term efficacy and safety of triple semicircular canal occlusion (TSCO) in the treatment of intractable Menieres disease (MD).Methodology: Thirty-two patients diagnosed with unilateral MD strictly meeting the Hearing and Equilibrium criteria issued by American Academy of Otolaryngology-Head and Neck Surgery Committee (1995) who referred to vertigo clinic of our hospital between Dec.2010 and Dec.2011 were enrolled in this study.Triple semicircular canal occlusion (TSCO) was performed in pathological ear for each patient.Vertigo control and auditory function were measured before and 2 years after surgery.Pure tone audiometry, caloric test, and vestibular evoked myogenic potential were performed for evaluation of audiological and vestibular function in two-years follow-up.Magnetic resonance imaging of the inner ear fluid water was performed after 2 years for the morphology of membranous labyrinth in the imaging of TSCO.