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Objective: To evaluate the feasibility and safety of laparoscopic resection of hilar cholangiocarcinoma.Materials and Methods: From March 2007 to April 2012, Laparoscopic resection of hilar cholangiocarcinoma was performed in seven cases with hilar cholangiocarcinoma.1 patient with type Bismuth Ⅰ, 3 patients with type BismuthⅡ, 1 patient with type Bismuth Ⅱb and 2 patients with type Bismuth Ⅳ.In the operation, the complete skeletonization of hepatoduodenal ligament was performed in all the cases.The reconstructions were performed with Roxn-en-Y approach with 2 cases (Bismuth Ⅰ and BismuthⅡ) in total laparoscopy, 3 cases (BismuthⅡ,Ⅲb, Ⅳ) in open approach by 3.0-4.0 incision on right upper quadrant, lcase (BismuthⅣ) in hand-assisted laparoscopic approach.Results: All the cases were performed resection laparoscopically successfully and certified negative margins by intraoperative frozen pathological examination.One cases combined left hepatectomy and two cases combined caudate lobectomy.None of the cases were converted to open surgery.The overall mean operating time was 7.1h (5.5-9.0h) and the mean intraoperative blood loss was 490ml (150-850ml).The mean postoperative length of stay was 16.9 days and the longest following up was 42 month.Conclusions: Laparoscopy could be the potential choice for hilar cholangiocarcinoma.And even combined hepatectomy and caudate lobectomy, resection of hilar cholangiocarcinoma could be performed feasible and safe in laparoscopy.