Fibrosis is a chronic and progressive process characterized by an excessive deposition of extracellular matrix(ECM)leading to overgrowth,hardening and scarring of various tissues.Fibrosis is a common pathological sequela of most chronic inflammatory diseases,and it ultimately leads to permanent scarring organ and progressive loss of function.Fibrotic changes may influence almost all tissues and organs,including the skin,kidney,lung,liver,as well as cardiac and vascular systems,eyes[1].Available data indicate that both genetic and environmental factors contribute to risk of Idiopathic Pulmonary Fibrosis(IPF)and other Idiopathic Interstitial Pneumonia(IIP).There has been great anticipation that identifying genetic links to fibrosis may help define etiologic factors,improve understanding of disease pathogenesis,and suggest potential treatment options.However,the rich scientific information about previously identified fibrosis-related genes is dispersed in thousands of publications.There is still no database focusing on fibrosis-related genes,which is why we constructed FRgAtlas database 1.0.We extracted 4002 genes and 65535 sentences from PubMed using the keywords of either fibrosis or its lexical variants,and initially identified several hundred genes that have certain connections with fibrosis after the preliminary manual curation.We believe this database will lead to new insights into the pathogenesis of fibrosis and will be useful for developing the therapeutics for fibrosis.