【摘 要】
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Hypoxia is a special feature occurring during acute and chronic vascular diseases and tumor growing.Angiogenesis, which is the process by formation of new blood vessels, is essential for adaptation of
【机 构】
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College of Pharmacy, Seoul National University South Korea
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Hypoxia is a special feature occurring during acute and chronic vascular diseases and tumor growing.Angiogenesis, which is the process by formation of new blood vessels, is essential for adaptation of tumor cells to hypoxic environment.Hypoxia-inducible factor-1α (HIF-1α), a key mediator of angiogenesis, is over expressed under hypoxia condition and transcripts various genes that concerned with survival and proliferation of tumor cells.Deguelin, a natural rotenoid, exhibits potent apoptotic and anti-angiogenic activities in a variety of transformed cells and cancer ceils.Deguelin also exhibits potent tumor suppressive effects in several human xenograft tumor models.
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