【摘 要】
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Objective To explore protection of carbachol to myocardium in patients with intestinal barrier dysfunction induced by emergency trauma.Methods Seventy patients after trauma with a definite diagnosis o
【机 构】
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ICU,ebei United University Affiliated Hospital,Tangshan,Hebei,063000
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Objective To explore protection of carbachol to myocardium in patients with intestinal barrier dysfunction induced by emergency trauma.Methods Seventy patients after trauma with a definite diagnosis of MODS in ICU were included, which were randomly divided into the carbachol treatment group (n=37) and mosapride citrate treatment group(n=33).DAO activity, expressions of CD11b and CD18 on PMN in peripheral blood and LVEF were detected on the 1 st and 7th day, as well as the peak contents of CK-MB.Clinical effects were observed.Results Compared to the mosapridc citrate treatment group, patients in the carbachol treatment group showed a significant improvement in intestinal pneumatosis and hydrops (P<0.05), together with a higher response rate on the 7th day.As well as a significant decline in the activity of DAO, the expressions ofCD1 1b and CD18 on PMN (P < 0.05).These were lower than mosapride citrate treatment group on the 7th day, and LVEF was higher than that group.The peak contents of CK-MB was lower than that of mosapride citrate treatment group.Conclusion o the patients of intestinal barrier dysfunction induced by emergency trauma, by lessening the ischemic/reperfusion injury, inhibiting the production of inflammatory cytokines in vivo, and promoting peristalsis of intestinal tract, carbachol could loosen the myocardium injury and protect remote organ-heart function.
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