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Objectives The present study was to investigate the effects of atorvastatin on BMP/Smad signalling in pulmonary arterial smooth muscle cells (PASMCs) derived from pulmonary artery hypertensive (PAH) rats.Methods PAH was induced by a single intraperitoneal injection of MCT at a dose of 40mg/Kg.Mean pulmonary arterial pressure (MPAP) was measured by catheterisation;right ventricular hypertrophy index (RVHI) were calculated [RVHI =RV/(LV +S)].