EFFECTS OF ATORVASTATIN ON BMP/SMAD SIGNALING IN PULMONARY ARTERIAL SMOOTH MUSCLE CELLS DERIVED FROM

来源 :第二十四届长城国际心脏病学会议、亚太心脏大会暨国际心血管病预防与康复会议(The 24th Great Wall Int | 被引量 : 0次 | 上传用户:chimaomao
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Objectives The present study was to investigate the effects of atorvastatin on BMP/Smad signalling in pulmonary arterial smooth muscle cells (PASMCs) derived from pulmonary artery hypertensive (PAH) rats.Methods PAH was induced by a single intraperitoneal injection of MCT at a dose of 40mg/Kg.Mean pulmonary arterial pressure (MPAP) was measured by catheterisation;right ventricular hypertrophy index (RVHI) were calculated [RVHI =RV/(LV +S)].
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