Lys29-Linked Nonproteolytic Poly-Ubiquitination of Axin by Smurf1 Negatively Regulates Wntβ-Catenin

来源 :2012全国发育生物学大会 | 被引量 : 0次 | 上传用户：binfeb91

【摘要】

：

　　The Wnt/3-catenin signaling pathway is highly conserved among eukaryotic organisms, which is essentially important for embryogenesis.Deregulation of the Wnt

【作者】

：

Cong Fei Lin Li

【机构】

：

StateKeyLaboratoryofMolecularBiology,InstituteofBiochemistryandCellBiology,ShanghaiInstitutesforBiol

【出处】

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2012全国发育生物学大会

【发表日期】

：

2012年10期

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论文部分内容阅读

　　The Wnt/3-catenin signaling pathway is highly conserved among eukaryotic organisms, which is essentially important for embryogenesis.Deregulation of the Wnt signaling pathway is linked to tumorigenesis and many other human diseases.Recently, the involvement of ubiquitin-mediated regulation has been emphasized in the Wnt/β-catenin signaling pathway.

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Lys29-Linked Nonproteolytic Poly-Ubiquitination of Axin by Smurf1 Negatively Regulates Wntβ-Catenin

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