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Objective To develop effective implants for delivery of 3,4-dihydro-3-methyl-4-oxoimidazo[5,1-d]-as-tetrazine-8-carboxamide (temozolomide; TM) with low initial burst and less neurotoxicity.Methods TM-loaded poly-propylene carbonate (PPC) fiber was fabricated by electrospinning.Some of the fiber sheets were then covered with alginate (ALG).Influences of several preparation parameters on drug delivery behavior were investigated.The micro-morphology of these fibers was studied using scanning electron microscopy and differential scanning calorimetry.In vitro release properties of two forms of samples were observed and their cytotoxicity against C6 glioma cells was assessed.