CXCR4拮抗多肽在白血病治疗中的应用研究

来源 :2013全国生物与医学纳米技术博士生学术论坛 | 被引量 : 0次 | 上传用户：AsiaIT

【摘要】

：

　　白血病是造血干细胞克隆性增殖的肿瘤性疾病,其侵袭、浸润和耐药性的产生是导致复发和病人死亡的重要原因之一。骨髓基质微环境可以介导白血病细胞的侵袭浸润,并保护白血

【作者】

：

李潇瑾郭花杨延莲孟洁刘健王琛许海燕

【机构】

：

中国医学科学院基础医学研究所-北京协和医学院基础学院生物医学工程系,北京100005国家纳米科学中心,北京100190

【出处】

：

2013全国生物与医学纳米技术博士生学术论坛

【发表日期】

：

2013年9期

【关键词】

：

白血病基质细胞衍生因子1 CXCR4 迁移粘附

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　　白血病是造血干细胞克隆性增殖的肿瘤性疾病,其侵袭、浸润和耐药性的产生是导致复发和病人死亡的重要原因之一。骨髓基质微环境可以介导白血病细胞的侵袭浸润,并保护白血病细胞免受化疗药物的杀伤,其中起关键作用的是基质细胞衍生因子1 (SDF-1,也称为CXCL12)及其特异性受体CXCR4所组成的CXCR4/CXCL12轴。白血病细胞表面高表达CXCR4,CXCR4与CXCL12的相互作用对白血病细胞的迁移、归巢、增殖、侵袭、浸润、耐药等行为具有重要的调控作用。

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CXCR4拮抗多肽在白血病治疗中的应用研究

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