ObjectiveThere is emerging evidence linking obstructive sleep apnea (OSA) to hypertension.The underlying pathophysiological mechanisms that link OSA to hypertension (HT) are not entirely understood.The aim of this study was to investigate thecharacteristics of polysomnographic values and synchronous blood pressure in patients of obstructive sleep apnea with hypertension.MethodsPolysomnography (PSG) and ambulatory monitor for measuring synchronous blood pressure were employed in the present study between OSA patients with HT (n=56)and withoutHT (n=50).ResultsThe alteration of blood pressure in OSA with HT characterized by diastolic blood pressure (DBP) ascension, and accompanied with arterial saturation oxygen (SaO2) decline, mainly occurred the period of later half of night (3:00-6:00 h), in meanwhile REM sleep is increasing.Apnea hyponea index (AHI), oxygen desaturation index (ODI), awake index (AI), wake after sleep onset (WASO) and the proportion of non-rapid eye movement sleep1 (N1) in total sleep time (TST) in OSA patients with HT were significantly increased (P<0.001), respectively compared to OSA without HT patients.However, the mean SaO2 (MSaO2), the lowest SaO2 (LSaO2), the proportion of slow wave sleep (SWS) and rapid eye movement (REM) sleep in TST were decreased (P<0.05) in OSA with HT compared to OSA without HT.There were positive correlations between the systolic/diastolic blood pressure (SBP/DBP) and AHI, ODI, AI, WASO and N1/TST (P<0.05).There were negative correlations between the SBP/DBP and MSaO2, LSaO2 (P<0.05).Conclusions There are significant differences between OSA with HT and OSA without HT in polysomnographic values.The alteration of blood pressure in OSA with HT characterized by diastolic blood pressure (DBP) ascension, and accompanied with arterial saturation oxygen (SaO2) decline, mainly occurred the period of later half of night (3:00-6:00 h), in meanwhile REM sleep is increasing.AHI is the high risk factor in OSA patients with HT.