It has been shown that essential hypertension (EH) is a complicated polygenic genetic disease.Furthermore, the genesis and development of EH has been well associated with the state of holistic health of body.We select the association between three key gene polymorphism of rennin-angiotensin system (RAS) and the syndrome of traditional Chinese medicine(TCM) in EH as our enter-point, analyze the relation between interaction of polygenic locus mutations and different syndrome in EH by a new genetic statistics, correlate the exterior and interior environmental malgenic factors in patients with EH with different syndrome and carry out an association analysis from the perspective of molecular epidemiology.In that way, we may reveal part of the scientific connotation of the substantial syndrome in EH.This can not only make us have a better apprehension of the mechanisms in physiology and pathology of the genesis in EH but also bring us a guidance on early diagnosis, prophylaxis, treatment in EH.Thus, it can provide us the proof in dialectical treatment by TCM to prevent and cure EH.