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The clinical issues for dealing with morbid obesity are reviewed.The regain of body weights after surgical treatments remains a puzzling focus.A Roux-en-Y Gastric Bypass(RYGB)rat model is considered to explore such phenomena.The model reproduces human bi-phasic weight-change.Three sets of rats are considered in the experiments,namely,treatment(RYGB),control(Obse)and pair-fed.Long period of observation of more than 120 days is taken,equivalent to 9-year of human life-span.