【摘 要】
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Three-dimensional structures and their stability are essential for the bio-logical functions of RNAs,and due to the polyanionic nature,salt condition is cri
【机 构】
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DepartmentofPhysics,WuhanUniversity,China
【出 处】
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数学生物物理及分子生物学研讨会(The Mathematical Biophysics and Molecular Bi
论文部分内容阅读
Three-dimensional structures and their stability are essential for the bio-logical functions of RNAs,and due to the polyanionic nature,salt condition is critical for RNA 3D structure and stability.However,there is still lack of a physical model for predicting 3D structure and stability of RNAs in salt solutions.In the work,we have proposed a coarse-grained model for predicting 3D structure and stability of RNAs,including RNA hairpins,duplexes and RNA pseudoknots,and the model can account for the effect of monovalent and divalent ions on their structures and stability.The predicted structures,and melting temperatures for RNA hairpins,duplexes and pseudoknots in various monovalent/divalent ion solutions are in excellent agreement with the extensive experimental measurements.
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