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目的:观察卡托普利逆转压力负荷增加大鼠心肌纤维化的作用。方法:采用腹主动脉狭窄所致压力负荷增加大鼠左室重构模型,将雄性SD大鼠36只随机分为假手术组、模型组、卡托普利组,观察用药4周后左室心肌病理形态胶原染色、左室心肌间质超微结构、左室心肌Ⅰ型胶原免疫组织化学染色
Objective: To observe the effect of captopril on reversing myocardial fibrosis in rats with stress load. Methods: Left ventricular remodeling was induced by pressure overload in abdominal aortic stenosis. Thirty-six male Sprague-Dawley rats were randomly divided into sham operation group, model group and captopril group. Left ventricular Myocardial pathological morphological collagen staining, left ventricular myocardial ultrastructure, left ventricular myocardial collagen type Ⅰ immunohistochemical staining