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Study Objectives: To determine the mortality and its risk factors in patients with rapid eye movement(REM)sleep behavior disorder(RBD).Methods: A total of 205 consecutive patients with video-polysomnography confirmed RBD(mean age = 66.4 ± 10.0 y,78.5#males)were recruited.Medical records and death status were systematically reviewed in the computerized records of the health care system.Standardized mortality ratio(SMR)was used to calculate the risk ratio of mortality in RBD with reference to the general population.