【摘 要】
：
One of the hallmarks of cancer is the ability of malignant cells to invade tissues, eventually leading to the establishment of secondary tumors far removed from
【机 构】
：
CenterforTheoreticalBiologicalPhysics,RiceUniversity,USA
【出 处】
：
8th IUPAP International Conference on Biological Physics(第八届
论文部分内容阅读
One of the hallmarks of cancer is the ability of malignant cells to invade tissues, eventually leading to the establishment of secondary tumors far removed from the initial site.As is well-known, death is usually associated with this metastatic spread.In this talk, we describe a recently derived model of a specific microRNA circuit involved in the epithelial-mesecnchymal transition (EMT), which creates motile cells of importance for both embryonic development and cancer metastasis.Our results imply that the form of the regulation allows in general for a hybrid intermediate state of the network, which we identify with cells undergoing collective motility and simultaneously exhibiting partial epithelial and mesenchymal phenotypes.At the end, we will mention how our results impact more generally on cell-fate decisions in the progressing tumor.
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