孕期烟雾暴露致子代发育毒性的胎盘发育机制及其防治研究

来源 :第八届海峡两岸毒理学研讨会 | 被引量 : 0次 | 上传用户:passkakaxi
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  发育毒性(developmental toxicology)指亲代接触外源因素对子代造成的有害作用,表现为发育生物体的生长迟缓、功能缺陷、结构异常甚至死亡。烟雾作为一种外源性发育毒物,不仅可导致婴儿猝死综合征、免疫系统异常,还可引起子代出生后神经精神性疾病、代谢性疾病的患病率增加。孕期烟雾暴露的胎盘发生机制包括:CPYs酶系表达增加造成胎盘氧化损伤;胎盘糖皮质激素屏障功能改变;胎盘上重要基因发生DNA甲基化改变。
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