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HCC(Hepatocellular Carcinoma)is one of the most common malignant tumors in the world.The alteration of sugar chain in cancer cells can lead to changes in cell biology characteristics.Glycosyl transferase is a kind of widely exists in the golgi apparatus and endoplasmic reticulum,which synthetise sugar chain of cell.N-acetyl glucosamine transferase-IVa(GnT IVa)is one of the glycosyl transferase which formed on the core of sugar chain beta 1,4 sugar chain branching structure.