The concept of "cooperative catalysis" has been recognized as one of the most powerful approaches for stimulating innovations to revolutionize the processes of pharmaceutical,material and chemical industries.[1]In this talk,several case studies in our lab on the design of highly efficient molecular catalysts and the development of new sustainable process on the basis of "cooperative catalysis" will be presented,including a chiral titanium catalyst for asymmetric ring-opening of epoxide,[2]an integrated Salen/M catalyst for asymmetric cyanation of aldehydes,[3]and a bifunctional SKP/Pd catalyst for asymmetric allylic amination of MBH adducts.