A biomimetic nanovector-mediated targeted cholesterol-conjugated siRNA delivery for tumor gene thera

来源 :2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会 | 被引量 : 0次 | 上传用户：terrychang2009

【摘要】

：

【作者】

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Wei Wang Yang Ding Jianping Zhou

【机构】

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State Key Laboratory of Natural Medicines,Department of Pharmaceutics,China Pharmaceutical Universit

【出处】

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2012年中国药物制剂大会——中国药学会药剂专业委员会年会、亚洲阿登制药技术研讨会暨国际控释协会中国分会年会

【发表日期】

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2012年10期

【关键词】

：

Reconstituted high density lipoprotein Apolipoprotein A-I Targeted cholesterol-c

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　　The study aimed to develop a biomimetic nanovector,reconstituted high density lipoprotein (rHDL),mediating targeted cholesterol-conjugated siRNA (Chol-siRNA) delivery for Pokemon gene silencing therapy.Chol-siRNA-loaded rHDL nanoparticles (rHDL/Chol-siRNA complexes) were prepared using thin-film dispersion method and their characteristics were investigated in detail.RHDL/Chol-siRNA complexes at the optimal volume ratio (lipid:Chol-siRNA) exhibited high Chol-siRNA-loading efficiency(~99%),desirable nanoparticle size and excellent stability in serum.

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