【摘 要】
：
The biological risks associated to the administration of viral vectors for gene therapy have restricted the further development of viral vectors and seriously challenged their incorporation to clinica
【机 构】
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IBB University Autonoma of Barcelone Spain
【出 处】
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2008中国深圳蛋白质和多肽科学大会
论文部分内容阅读
The biological risks associated to the administration of viral vectors for gene therapy have restricted the further development of viral vectors and seriously challenged their incorporation to clinical trials.Non viral gene therapy is a safer alternative to the use of viruses for gene delivery,although the low gene expression levels achieved through the use of viral vectors is a main obstacle for their application,and need to be largely improved to reach therapeutic levels.There are many types of non viral vectors depending on the chemical nature of the vehicle itself,including those based in liposomes,dendrimers or proteins.Recently,the Artificial virus concept has been proposed to describe nanocomplexes for targeted gene delivery that mimic the critical viral functions for nucleic acid transport.
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