The generation of neocortex interneurons approximately starts from E9.5 and ends at E18.5.Previous studies have revealed that a portion of early generated interneurons(EGIns)in the hippocampus can act as hub neurons which may modulate the synchronized activity of the hippocampus network.However,the functional significance of EGIns in neocortex is not well understood.In this study,combining fast multi-scale calcium imaging(fMCI)with whole cell recording,we found that some EGIns in the neocortex also have hub function.On the basis of electrophysiological and morphological data,we observed that EGIns have a higher connectivity level than ordinary generated interneurons(OGIns)which were born around the peak of neurogenesis.Nevertheless,this advantage of EGIns almost only occurs in the first postnatal week and disappears later when the neocortex gets more mature.Our results implied that EGIns have a stronger regulatory function in the developing neocortex at early postnatal stage when vast cortical synaptic network begin to establish.