ZnT8介导的睾丸间质细胞线粒体锌转运参与睾酮合成的机制研究

来源 :第一届生物微量元素研讨会 | 被引量 : 0次 | 上传用户：wahuhihi

【摘要】

：

目的:(1) 发现并证实睾酮合成相关新的锌转运体——ZnT8.(2) 阐明ZnT8 参与睾酮合成的机制.方法:应用免疫荧光双标和激光共聚焦扫描显微镜及Western Blot 技术获取ZnT8 在小

【作者】

：

池志宏王占友

【机构】

：

中国医科大学病理生理学教研室,110001

【出处】

：

第一届生物微量元素研讨会

【发表日期】

：

2012年11期

【关键词】

：

阿尔茨海默病 APP/PS1 转基因小鼠 APP 转基因细胞二价金属离子转运体 Aβ RNA 干扰

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

目的:(1) 发现并证实睾酮合成相关新的锌转运体——ZnT8.(2) 阐明ZnT8 参与睾酮合成的机制.方法:应用免疫荧光双标和激光共聚焦扫描显微镜及Western Blot 技术获取ZnT8 在小鼠睾丸间质细胞分布和表达的证据;应用hCG腹腔注射乳鼠诱导的睾酮生成动物模型,采用锌离子自显影技术以及免疫组织化学技术等,获取ZnT8 及锌离子参与睾酮合成的证据.

其他文献

Ndfip1 mediated DMT1 degradation reduces iron accumulation in 6-OHDA treated MES23.5 cells

Elevated iron accumulation and increased divalent metal transporter 1 (DMT1) expression have been reported in the substantia nigra (SN) in Parkinson’s disease

会议

DMT1参与β-淀粉样前体蛋白表达和Aβ分泌的机制研究

目的:通过形态学和分子生物学技术对DMT1-IRE 和DMT1-nonIRE 在AD 病人和APP/PS1 转基因小鼠脑内的表达变化、定位分布及与Aβ 的相关性进行系统分析;以转染APPsw 基因的SH-S

会议

阿尔茨海默病APP/PS1 转基因小鼠APP 转基因细胞二价金属离子转运体AβRNA 干扰

锌和锌螯合剂影响阿尔茨海默病转基因小鼠脑内Aβ沉积的机制研究

阿尔茨海默病 (Alzheimer’s disease,AD)的主要病理学标志是大脑神经元外部出现以Aβ (amyloid-β) 为核心成分的老年斑.Aβ 是由Aβ 前体蛋白(amyloid-β precursor protei

会议

阿尔茨海默病AD 转基因小鼠锌氯碘羟喹老年斑

Aktnrf2 activated upregulation of heme oxygenase-1 involves in the role of rg1 against ferrous iron-

Iron accumulation is considered to be involved in the pathogenesis of Parkinson’s disease (PD).The aim of present study is to investigate the mechanism involve

会议

Ferristatin Attenuates Amyloidogenic Pathway via Inhibiting Divalent Metal Transporter 1

Dysregulation of iron homeostasis is involved in the pathological process of Alzheimer’s disease (AD).We have recently reported that divalent metal transporter

会议

Alzheimer’s diseaseDivalent metal transporter 1Ferristatin

Overexpression of mitochondrial ferritin inhibited the tumour cell proliferation by regulation of ce

Objective: To study the mechanism of overexpression of mitochondrial ferritin(MtFt) for inhibiting euroblastoma cells proliferation.Method: electedtFt-SY5Y cell

会议

Novel frataxin isoforms may contribute to the pathological mechanism of Friedreich ataxia

Friedreich ataxia (FRDA) is an autosomal recessive neurodegenerative disease caused by reduced expression levels of the frataxin gene (FXN) due to expansion of

会议

Graphene oxide provokes necrosis via cytoskeleton disruption and oxidative stress

Graphene oxide (GO) displays promising properties for biomedical applications including drug delivery and cancer therapeutics.However,GO exposure also raises sa

会议

Characterization of the GufA Subfamily Member SLC39A11Zip11 as a Novel Zinc Transporter

Cellular zinc influx and efflux are maintained by two major transporter families,ZIP (SLC39A) and ZnT (SLC30A or CDF).The functions for ZIP11/SLC39A11 remain un

会议

Zinc transporterSLC39A11/ZIP11ZIP familyMREMTF-1Zinc homeostasis

Ferritin is the key player of dietary iron absorption and tissue iron detoxification in Drosophila m

Iron is an essential element but possesses potential toxicity for aerobic lives.Ferritin,a large protein complex with high capacity of iron incorporation,can se

会议

ZnT8介导的睾丸间质细胞线粒体锌转运参与睾酮合成的机制研究

与本文相关的学术论文