Mechanism-based inactivation of CYP2C9 by linderane

来源 :2015第11届全国药物和化学异物代谢学术会议 | 被引量 : 0次 | 上传用户:a372092
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  Linderane (LDR), a furan-containing sesquiterpenoid, is found in Lindera aggregata (Sims) Kosterm, a common traditional Chinese herbal medicine.
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Many furan-containing compounds are known to be toxic and/or carcinogenic.Metabolic activation of toxic furans to cis-enediones (cis-enedials or γ-ketoenals) is generally considered as the initial ste