【摘 要】
：
Objective:To evaluate the effects of oral PeptanTM collagen peptides for 6 months on knee joint pain and function in female patients with knee osteoarthritis(OA).Methods:a prospective,double-blind,ran
【机 构】
：
Department of Orthopaedics,Shanghai Jiao Tong University Affiliated Sixth People's Hospital;Departm
【出 处】
：
第十一届国际骨矿研究学术会议暨第十三届国际骨质疏松研讨会
论文部分内容阅读
Objective:To evaluate the effects of oral PeptanTM collagen peptides for 6 months on knee joint pain and function in female patients with knee osteoarthritis(OA).Methods:a prospective,double-blind,randomized,placebo-controlled study was conducted at the 6th Peoples Hospital affiliated to.100 eligible female OA subjects selected through screening were included in the study and sighed informed consent.The subjects received either PeptanTM collagen peptides(CP) 8g (n=50) or placebo (n=50) daily for 6 months.Each subject was evaluated for knee joint pain and function by using the standard tools (WOMAC scores and Lysholm scores) and assessment the joint symptoms and physical finction at the baseline (month 0),and months 3 and 6.Results:The data from all subjects (n=95) were evaluated.WOMAC score and Lysholm score showed statistically significant difference with the CP group(n=48) compared with the placebo group(n=47)who treated for 6 months:CP group vs placebo group (WOMAC score 11.33±4.28 vs 15.00±3.45) and Lysholm score 85.24±8.88 vs 79.73±9.62) (P<0.001).However,no significant difference between two groups for 3 months was found (P>0.05).Moreover,the proportion of clinical effect was also found significant difference between the placebo group and the CP group.Conclusion:our study suggested that taking collagen peptides 8g/d for 6 months can improve knee joint pain and function in subjects with knee osteoarthritis.
其他文献
目的：观察桂枝芍药知母汤联合西药治疗80例类风湿关节炎(RA)12周后的疗效和安全性.方法将活动期类风湿关节炎患者随机分为治疗组40例和对照组40例，治疗组给予桂枝芍药知母汤、甲氨喋呤片(MTX)、来氟米特联合治疗，对照组给予MTX、来氟米特.治疗12周以后，采用超声仪对患者受累掌指关节或近端指间关节的滑膜厚度、滑膜内血管翳和血流信号RI进行检测观察，同时评价DAS28和HAQ评分.结果：超声检测
本文针对脑卒中诱发骨质疏松症的发病机制进行综述。脑卒中偏瘫患者并发骨矿化密度下降、骨质疏松症的危险因素除运动减少、维生素D缺乏、钙离子代谢异常之外，还有性别、遗传、生活方式、饮食习惯、等多种因素有关。其中废用对骨质的影响是非常明显的，长期卧床或者肢体活动障碍的老年患者，骨矿物质含量呈进行性减少，故应该鼓励脑卒中患者尽早开始康复训练，必要时还可辅以抗骨质疏松药物治疗，如钙剂和维生素D,骨吸收抑制剂、
Sclerostin is a negative regulator of bone formation.Previous studies demonstrated that treatment with a sclerostin monoclonal antibody (Sc(1)-Ab) results in significantly increased bone formation,bon
目的：探究肝素对慢性肾病大鼠骨骼的影响.方法：40只3月龄雄性SD大鼠随机分成正常对照组(Normal),慢性肾病组(CKD),低剂量肝素组(L-UFH),高剂量肝素组(H-UFH).四组均给予高磷饮(1.03％)食,饲养6周;CKD组食物中加腺嘌呤(0.75％),连续四周;第二周开始,Normal组、CKD组皮下注射生理盐水,L-UFH和H-UFH在CKD模型的基础上,分别皮下注射lU/g/Kg
目的：分析人体血清中肠源性性5-羟色胺(5-HT)与各部位骨密度(BMD)、骨代谢生化指标总I型前胶原氨基端肽(PINP)、β-胶原降解产物(β-Crosslaps)、甲状旁腺素(PTH)及25-羟基维生素D(25(OH)D)等的相关性.方法：①本研究选入样本数540例,最后纳入研究的350例.所有样本为2011年5月-2012年12月间到广州军区广州总医院住院部及门诊部就诊的20～90岁的人群.
目的 跟骨定量超声骨密度测定经济、方便，适用于人群骨质疏松症的筛查，确定合理的筛查阈值将有利于骨质疏松症患者的诊断和医疗资源的合理使用.方法对236例绝经后妇女做双能X线吸收法(DXA)骨密度检测腰椎和髋部骨密度，同期做跟骨超声骨密度测量(QUS)，比较不同QUS均值时诊断骨质疏松症的敏感性和特异性.结果 达骨质疏松症诊断标准DXA T≤-2.5时，跟骨QUS T≤-1.0、-1.5、-2.0、-
目的：评估维生素D3(Vita D3)1200IU/天对维生素D不足的绝经后妇女血清25羟维生素D[25(OH)D]水平和骨转换的作用.方法：60名维生素D不足的绝经后妇女平均年龄69.4±1.3岁,根据年龄分成二组。A组30名,年龄75.2±3.4岁和B组30名,年龄63.6±5.1岁,均接受Vita D31200 IU/天和钙尔奇D1片/天(每片含600mg元素钙和Vita D3 125IU)
目的：通过调查中国福建莆田地区健康人群血清25羟维生素D及PTH水平与骨密度,分析莆田地区畲族人群在冬季维生素D的状态并评价其与骨密度关系。方法：于2010年10月至12月,调查613例畲族人群,其中男183例,女430例,年龄10～94岁,平均年龄55.96±15.51.应用罗氏公司的器械和试剂,抽血检查血清25羟维生素D (250HD)、甲状旁腺激素(PTH).同时应用美国Osdeometer